The combined characteristics of PRO-VET HYPERSEN makes this ration useful in the treatment of various canine disorders. Food hypersensitivity and atopy often co-exist in cats and it is difficult to distinguish definitively between the two conditions. PRO-VET HYPERSEN makes it possible to treat both patients with food hypersensitivity and those with atopy.
Chopping proteins into smaller peptide fragments decreases their antigenicity. This principle extends to cats with food hypersensitivity. Cats with hypersensitivity towards soy protein developed pruritis upon ingesting the intact protein, but did not do so with hydrolysed soy protein.
PRO-VET HYPERSEN is hypoallergenic diet which contains hydrolysed proteins which have been used as elimination diet. So far elimination diets with hydrolysed and parent proteins have not been compared directly, but based on data for elimination diets with intact and hydrolysed proteins it could be suggested that hypoallergenic diets as PRO-VET HYPERSEN with hydrolysed proteins is more effective than those with intact proteins in the management of food hypersensitivity.

Atopy and food hypersensitivity often go hand in hand and have similar clinical signs, but skin disorders caused by inhaled allergens will not react to hypoallergenic protein sources. The treatment of atopic dermatitis involves the suppression of chronic inflammatory reactions in the skin. PRO-VET HYPERSEN contents eicosanoids formed from di-homo-gamma linolenic acid and from eicosapentaenoic acid (EPA) so that PRO-VET HYPERSEN has an anti-inflammatory properties.

Double blind, placebo-controlled experiments in cats with atopic dermatitis have shown that supplements of both borage oil, which is rich in gamma-linolenic acid (GLA) and fish oil, which is rich in EPA, lower the severity of pruritis, erythema and self-trauma. Good results have been obtained with a diet rich in both fish oil and borage oil. PRO-VET HYPERSEN contains about 0.5% borage oil and 5% fish oil. The efficiancy of PRO-VET HYPERSEN was tested in four clinics using a double blind, placebo-controlled design. After 10 weeks on the diet, the scores for pruritis and erythema had decreased to about half, while the control treatment had no influence. According to the owners the diet had improved skin condition by 60% of the cats. Clearly, a substantial number of the patients with atopic dermatitis will improve after feeding PRO-VET HYPERSEN enriched with suitable amounts of fish oil and borage oil. However, there will be great differences in individual responsiveness.

By cats with idiopathic chronic colitis or inflammatory bowel disease, the feeding of a hypoallergenic diet as PRO-VET HYPERSEN based on a hydrolysed protein source caused a significant decrease in clinical signs. Ingestion of fish oil may be expected to further improve the clinical condition through its anti-inflammatory activity. By humans with ulcerative colitis such a positive effect has been demonstrated.

Efficacy

Composition

rice, hydrolysed fish protein, potato protein, animal fat, fish oil (salmon), dried beet pulp, potato starch, minerals, hydrolysed chicken liver, purified vegetable fiber (cellulose), mannan-oligosaccharides, borage seed oil, lineseed oil, inulin (source of fructo-oligosaccharides).

With oxidation reducing substance tocopherol-rich extract of natural origin (Vitamin E) and preservatives ammonium propionate, phosphoric acid and citric acid. PRO-VET^.® products meet the requirements as stated by AAFCO, NRC and/of FEDIAF. Produced and packed in Holland, production takes place under certification of: NEN ISO 9001 / GMP +.

Analyses

Energy value 4284 Kcal/kg [17.9 MJ/kg]
pH urinary = ca 6,3

Vitamins:
Vitamin A (3a672a) (retinyl acetate)
Vitamin D3 (E671) (cholecalciferol)
Vitamin E (3a700) (all-rac-alpha-tocopherol)
Vitamin K3 (3a711) (menadione nicotinamide bisulfite)

Trace elements:
E1 Iron (Fe) (iron-(II)-sulphate monohydrate) 100 mg/kg
E5 Manganese (Mn) (manganese-(II)-oxide) 40 mg/kg
E4 Copper (Cu) (cupric-(II)-sulphate pentahydrate) 5.0 mg/kg
E6 Zinc (Zn) (zinc sulphate monohydrate) 150 mg/kg
E2 Iodine (I) (potassium iodide) 1.0 mg/kg
E8 Selenium (Se) (sodium selenite) 0.20 mg/kg

Technological additives:
Ammonium Chloride 4.0 gr/kg

Sensory additives:
Yucca Schidigera extract 125 mg/kg

Other nutritional additives:
L-Carnitine 750 mg/kg
Taurine 750 mg/kg

Feeding guide

Body     weight	Daily     portion
2 kg	30 - 40 gr
3 kg	40 - 55 gr
4 kg	50 - 70 gr
5 kg	60 - 85 gr
>6 kg	10 - 15 gr/kg

The recommended duration of feeding this diet is 3 to 8 weeks; if the signs disappear this feed can be used indefinitely.